Many features of cell behavior are regulated by Rho family GTPases, but the most profound
effects of these proteins are on the actin cytoskeleton and it was these that first drew …

Observations from different brain areas have established that the adult nervous system can
undergo significant experience-related structural changes throughout life. Less familiar is …

Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover
heritable traits that are related to genetic susceptibility to OCD. Deficient response inhibition …

The spread of cancer cells to distant sites in the body is the major cause of cancer patient
death. Growing evidence connects specialized subcellular structures, invadopodia, to …

Protein kinase C (PKC) isoforms are central components in intracellular networks that
regulate a vast number of cellular processes. It has long been known that in most cell types …

The cytoskeleton is a phylogenetically well‐preserved structure that plays a key role in cell
physiology. Dynamic and differential changes in cytoskeletal organization occur in cellular …

Phorbol ester induces actin cytoskeleton rearrangements in cultured vascular smooth
muscle cells. Calponin and SM22 α are major components of differentiated smooth muscle …

The involvement of Src, Cdc42, RhoA and PKC in the regulation of podosome assembly has
been identified in various cell models. In endothelial cells, the ectopic expression of …

Extracellular macromolecules, pathogens and cell surface proteins rely on endocytosis to
enter cells. Key steps of endocytic carrier formation are cargo molecule selection, plasma …

Phorbol ester triggers the conversion of focal adhesions into podosomes in A7r5 smooth
muscle cells. Here we followed the dynamics of podosome formation using dual …