Activation or exhaustion of CD8+ T cells in patients with COVID-19
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
The diverse function of PD-1/PD-L pathway beyond cancer
The recent success of PD-1 and PD-L1 blockade in cancer therapy illustrates the important
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses
Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory
B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper …
B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper …
Immune checkpoint blockade in infectious diseases
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
Immune checkpoints and their inhibition in cancer and infectious diseases
The development of chronic infections and cancer is facilitated by a variety of immune
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …
Epidemiology and immune pathogenesis of viral sepsis
GL Lin, JP McGinley, SB Drysdale… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …
The PD-1/PD-L1 axis and virus infections: a delicate balance
G Schönrich, MJ Raftery - Frontiers in cellular and infection …, 2019 - frontiersin.org
Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion
of tumor cells from antitumor immunity. Less well appreciated is the fact that the PD-1/PD-L1 …
of tumor cells from antitumor immunity. Less well appreciated is the fact that the PD-1/PD-L1 …
Lymphopenia caused by virus infections and the mechanisms beyond
Z Guo, Z Zhang, M Prajapati, Y Li - Viruses, 2021 - mdpi.com
Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …
Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer
JH Newman, CB Chesson, NL Herzog… - Proceedings of the …, 2020 - National Acad Sciences
Reprogramming the tumor microenvironment to increase immune-mediated responses is
currently of intense interest. Patients with immune-infiltrated “hot” tumors demonstrate higher …
currently of intense interest. Patients with immune-infiltrated “hot” tumors demonstrate higher …
LC3-associated phagocytosis in myeloid cells promotes tumor immune tolerance
Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of
cancer therapy. However, components of canonical autophagy play roles in other biological …
cancer therapy. However, components of canonical autophagy play roles in other biological …