High fat rodent models of type 2 diabetes: from rodent to human

NL Stott, JS Marino - Nutrients, 2020 - mdpi.com
Poor dietary habits contribute to increased incidences of obesity and related co-morbidities,
such as type 2 diabetes (T2D). The biological, genetic, and pathological implications of T2D …

Systematic review of transcriptome and microRNAome associations with gestational diabetes mellitus

KA Lewis, L Chang, J Cheung, BE Aouizerat… - Frontiers in …, 2023 - frontiersin.org
Purpose Gestational diabetes (GDM) is associated with increased risk for preterm birth and
related complications for both the pregnant person and newborn. Changes in gene …

[HTML][HTML] Potential roles of Adipocyte Extracellular vesicle–derived miRNAs in obesity-mediated insulin resistance

Y Kim, OK Kim - Advances in Nutrition, 2021 - Elsevier
Recently, extracellular microRNAs (miRNAs) from adipose tissue have been shown to be
involved in the development of insulin resistance. Here, we summarize several mechanisms …

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

S Yamaguchi, D Zhang, A Katayama… - Frontiers in …, 2022 - frontiersin.org
MicroRNAs expressed in adipocytes are involved in transcriptional regulation of target
mRNAs in obesity, but miRNAs critically involved in this process is not well characterized …

Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight

AI Doncheva, S Romero… - Acta …, 2022 - Wiley Online Library
Extracellular vesicles induced by exercise have emerged as potential mediators of tissue
crosstalk. Extracellular vesicles and their cargo miRNAs have been linked to dysglycemia …

Intramuscular injection of miR-1 reduces insulin resistance in obese mice

AC Rodrigues, AR Spagnol, FT Frias… - Frontiers in …, 2021 - frontiersin.org
The role of microRNAs in metabolic diseases has been recognized and modulation of them
could be a promising strategy to treat obesity and obesity-related diseases. The major …

MicroRNAs: the link between the metabolic syndrome and oncogenesis

A Fodor, AL Lazar, C Buchman, B Tiperciuc… - International Journal of …, 2021 - mdpi.com
Metabolic syndrome (MetS) represents a cluster of disorders that increase the risk of a
plethora of conditions, in particular type two diabetes, cardiovascular diseases, and certain …

Hypoxia treatment and resistance training alters microRNA profiling in rats skeletal muscle

T Mei, Y Hu, Y Zhang, Y Li - Scientific Reports, 2024 - nature.com
MicroRNAs (miRNAs) may play a crucial regulatory role in the process of muscle atrophy
induced by high-altitude hypoxia and its amelioration through resistance training. However …

MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program

KA Lewis, BM Stroebel, L Zhang, B Aouizerat… - International Journal of …, 2024 - mdpi.com
The Diabetes Prevention Program (DPP) randomized controlled trial demonstrated that
metformin treatment reduced progression to type 2 diabetes (T2D) by 31% compared to …

Hypoxia-Induced Skeletal Muscle Atrophy and Evaluating the Efficacy of Resistance Training: Insights from microRNA Expression Profiling and Bioinformatics …

T Mei, Y Hu, Y Zhang, Y Li - 2023 - researchsquare.com
MicroRNAs (miRNAs) may play a crucial regulatory role in the process of muscle atrophy
induced by high-altitude hypoxia and its amelioration through resistance training. However …