Human tissue kallikreins (hKs), which are encoded by the largest contiguous cluster of
protease genes in the human genome, are secreted serine proteases with diverse …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases
and are present in at least six mammalian orders. In humans, tissue kallikreins (hK) are …

Prostate specific antigen (PSA) or human kallikrein 3 (hK3) has long been an effective
biomarker for prostate cancer. Now, other members of the tissue kallikrein (KLK) gene family …

Human tissue kallikreins (KLKs) are attracting increased attention due to their role as
biomarkers for the screening, diagnosis, prognosis, and monitoring of various cancers …

Human tissue kallikrein genes, located on the long arm of chromosome 19, are a subgroup
of the serine protease family of proteolytic enzymes. Initially thought to consist of three …

Cancer is the second leading cause of death with 14 million new cases and 8.2 million
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …

Tissue kallikrein (KLK1) and kallikrein-related peptidases (KLK2–15) comprise a family of 15
highly conserved secreted serine proteases with similar structural characteristics and a wide …

Kallikreins are a subgroup of serine proteases that are involved in the post-translational
processing of polypeptide precursors. Growing evidence suggests that many kallikreins are …

Background Inflammation has significant roles in all phases of tumor development, including
initiation, progression and metastasis. Interleukin-10 (IL-10) is a well-known immuno …