Neurodegenerative disorders such as Alzheimer's disease (AD), Lewy body diseases (LBD),
and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are …

Neurodegeneration is a condition of the central nervous system (CNS) characterized by loss
of neural structures and function. The most common neurodegenerative disorders (NDDs) …

Previous studies on Parkinson's disease mechanisms have shown dysregulated
extracellular transport of α-synuclein and growth factors in the extracellular space. In the …

Search for a definitive cure for neurodegenerative disorders like Parkinson's disease (PD)
has met with little success. Mitochondrial dysfunction and elevated oxidative stress precede …

Patients with lower-risk myelodysplastic syndromes (LR-MDS) have a generally favorable
prognosis; however, a small proportion of cases progress rapidly. This study aimed to define …

Transcriptomics in Parkinson's disease offers insights into the pathogenesis of Parkinson's
disease but obtaining brain tissue has limitations. In order to bypass this issue, we profile …

Extracellular vesicles (EVs) play a crucial role in intercellular communication, participating in
the paracrine trophic support or in the propagation of toxic molecules, including proteins …

Background The mechanisms underlying neurodegeneration in the striatum of Huntingon's
Disease (HD) brain are currently unknown. While the striatum is massively degenerated in …

Background Although a pivotal role of microRNA (miRNA, miR) in the pathogenesis of
Huntington's disease (HD) is increasingly recognized, the molecular functions of miRNAs in …

Description of robust transcriptomic alterations in Huntington's disease is essential to identify
targets for biochemical studies and drug development. We analysed publicly available …