Abstract Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-
membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is …

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that is critically involved in the
embryonic development of the cardiovascular and central nervous systems. In the adult, S1P …

BACKGROUND AND PURPOSE BAF312 is a next‐generation sphingosine 1‐phosphate
(S1P) receptor modulator, selective for S1P1 and S1P5 receptors. S1P1 receptors are …

Abstract Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that
transmits signals through a family of G-protein-coupled receptors to control cellular …

Sphingolipids have emerged as molecules whose metabolism is regulated leading to
generation of bioactive products including ceramide, sphingosine, and sphingosine-1 …

Sphingosine kinases (SphK) 3 are prototypical members of a highly conserved family of
signaling enzymes. They are present in organisms as diverse as mammals, flies, worms …

The moniker lysophospholipid incorporates two broad families of membrane-derived lipids:
the glycerophospholipids and the sphingolipids. 1 Primary representatives of these two arms …

Sphingolipids and their synthetic enzymes are emerging as important mediators in
inflammatory responses and as regulators of immune cell functions. In particular …

Multiple Sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous
system (CNS) through demyelination and neurodegeneration. Until recently, major …

OBJECTIVES The histologic criterion of> 20 eosinophils per high power field (hpf) is
presently believed to establish the diagnosis of idiopathic eosinophilic esophagitis (IEE) …