Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …

INTRODUCTION Alzheimer's disease (AD) is the most common form of age-related
dementia, characterized by cognitive impairment, neurodegeneration, β-amyloid (Aβ) …

Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …

In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain.
In the previous year, a paired helical filament (PHF) protein had been identified in …

The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …

Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …