Autoimmune diseases such as multiple sclerosis (MS), type I diabetes (T1D), inflammatory
bowel diseases (IBD), and rheumatoid arthritis (RA) are chronic, incurable, incapacitating …

Cytokines are known for their pleiotropic effects. They can be classified by their function as
pro-inflammatory, such as tumor necrosis factor (TNF), interleukin (IL) 1 and IL-12, or anti …

The microbiome is a predictor of clinical outcome in patients receiving allogeneic
hematopoietic stem cell transplantation (allo-SCT). Microbiota-derived metabolites can …

The stimulator of interferon genes (STING) pathway has been proposed as a key regulator of
gastrointestinal homeostasis and inflammatory responses. Although STING reportedly …

The microbiota, comprising bacteria, fungi, and viruses residing within our bodies, functions
as a key modulator in host health and states, including immune responses. Studies have …

CD11c is a canonical dendritic cell (DC) marker with poorly defined functions in the immune
system. Here, we found that blocking CD11c on human peripheral blood mononuclear cell …

Introduction Acute graft-versus-host disease (aGVHD) is a major complication of post-
allogeneic hematopoietic stem cell transplantation (allo-HSCT) that severely impacts patient …

Pediatric allogeneic hematopoietic stem cell transplantation (HSCT) patients often suffer
from gastro-intestinal (GI) disease caused by viruses, Graft-versus-Host Disease (GVHD) or …

The intestine can be the target of several immunologically mediated diseases, including
graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD). GVHD is a life …

Despite strong biological rationale for the use of type-I IFNs for the treatment of acute
myeloid leukemia (AML), their usage is limited to few hematologic malignancies. Here, we …