Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

Covalent chemical probes are important tools in chemical biology. They range from post-
translational modification (PTM)-derived metabolic probes, to activity-based probes and …

Cysteine is the most intrinsically nucleophilic residue in proteins and serves as a mediator
against increasing reactive oxygen species (ROS) via reversible thiol oxidation. Despite the …

Alkyne tags have been widely used for the enrichment of labeled proteins to enable their
profiling at a proteome‐wide scale by mass spectrometry. The key component in the …

Peptides and proteins are involved in almost all biological events. In this review, three
chemical biology tools, which were developed for peptide/protein sciences from a viewpoint …

An N-sulfanylethylanilide-based traceable linker, developed to facilitate identification of
target proteins of bioactive compounds, was introduced into an alkynylated target protein …

Cyclic acetals based biomaterial without acidic products during hydrolytic degradation is a
promising candidate for tissue engineering applications; however, low hydrophilicity is still …

Elucidation of biological functions of peptides and proteins is essential for understanding
peptide/protein‐related biological events and developing drugs. Caged peptides and …

Biotinylation of amines is widely used to conjugate biomolecules, but either the resulting
label is non‐removable or its removal leaves a tag on the molecule of interest, thus affecting …

Here we report an example of a protein–PEG conjugate with a biotin tag cleavable by lipase-
catalyzed hydrolysis. Very mild cleavage conditions, heterogeneous, easily separable …