Portable nanopore-sequencing technology: Trends in development and applications
P Chen, Z Sun, J Wang, X Liu, Y Bai, J Chen… - Frontiers in …, 2023 - frontiersin.org
Sequencing technology is the most commonly used technology in molecular biology
research and an essential pillar for the development and applications of molecular biology …
research and an essential pillar for the development and applications of molecular biology …
Detection of m6A from direct RNA sequencing using a multiple instance learning framework
RNA modifications such as m6A methylation form an additional layer of complexity in the
transcriptome. Nanopore direct RNA sequencing can capture this information in the raw …
transcriptome. Nanopore direct RNA sequencing can capture this information in the raw …
Exploring N6-methyladenosine (m6A) modification in tree species: opportunities and challenges
Abstract N 6-methyladenosine (m6A) in eukaryotes is the most common and widespread
internal modification in mRNA. The modification regulates mRNA stability, translation …
internal modification in mRNA. The modification regulates mRNA stability, translation …
Simultaneous nanopore profiling of mRNA m6A and pseudouridine reveals translation coordination
Abstract N6-methyladenosine (m6A) and pseudouridine (Ψ) are the two most abundant
modifications in mammalian messenger RNA, but the coordination of their biological …
modifications in mammalian messenger RNA, but the coordination of their biological …
Exploring the epitranscriptome by native RNA sequencing
Chemical RNA modifications, collectively referred to as the “epitranscriptome,” are essential
players in fine-tuning gene expression. Our ability to analyze RNA modifications has …
players in fine-tuning gene expression. Our ability to analyze RNA modifications has …
Enhanced detection of RNA modifications and read mapping with high-accuracy nanopore RNA basecalling models
In recent years, nanopore direct RNA sequencing (DRS) became a valuable tool for
studying the epitranscriptome, owing to its ability to detect multiple modifications within the …
studying the epitranscriptome, owing to its ability to detect multiple modifications within the …
Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling
Nucleotides in RNA and DNA are chemically modified by numerous enzymes that alter their
function. Eukaryotic ribosomal RNA (rRNA) is modified at more than 100 locations …
function. Eukaryotic ribosomal RNA (rRNA) is modified at more than 100 locations …
Native RNA nanopore sequencing reveals antibiotic-induced loss of rRNA modifications in the A-and P-sites
The biological relevance and dynamics of mRNA modifications have been extensively
studied; however, whether rRNA modifications are dynamically regulated, and under which …
studied; however, whether rRNA modifications are dynamically regulated, and under which …
Epitranscriptomics in parasitic protists: role of RNA chemical modifications in posttranscriptional gene regulation
C Catacalos, A Krohannon, S Somalraju… - PLoS …, 2022 - journals.plos.org
“Epitranscriptomics” is the new RNA code that represents an ensemble of posttranscriptional
RNA chemical modifications, which can precisely coordinate gene expression and …
RNA chemical modifications, which can precisely coordinate gene expression and …
De novo basecalling of m6A modifications at single molecule and single nucleotide resolution
ABSTRACT RNA modifications hold pivotal roles in shaping the fate and function of RNA
molecules. Although nanopore sequencing technologies have proven successful at …
molecules. Although nanopore sequencing technologies have proven successful at …