Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

[HTML][HTML] The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

DNA origami: scaffolds for creating higher order structures

F Hong, F Zhang, Y Liu, H Yan - Chemical reviews, 2017 - ACS Publications
DNA has become one of the most extensively used molecular building blocks for
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …

Geometry of a DNA Nanostructure Influences Its Endocytosis: Cellular Study on 2D, 3D, and in Vivo Systems

A Rajwar, SR Shetty, P Vaswani, V Morya, A Barai… - ACS …, 2022 - ACS Publications
Fabrication of nanoscale DNA devices to generate 3D nano-objects with precise control of
shape, size, and presentation of ligands has shown tremendous potential for therapeutic …

Biotechnological mass production of DNA origami

F Praetorius, B Kick, KL Behler, MN Honemann… - Nature, 2017 - nature.com
DNA nanotechnology, in particular DNA origami, enables the bottom-up self-assembly of
micrometre-scale, three-dimensional structures with nanometre-precise features 1, 2, 3, 4, 5 …

[HTML][HTML] Nanoscale self-assembly for therapeutic delivery

S Yadav, AK Sharma, P Kumar - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Self-assembly is the process of association of individual units of a material into highly
arranged/ordered structures/patterns. It imparts unique properties to both inorganic and …

Challenges and perspectives of DNA nanostructures in biomedicine

A Keller, V Linko - Angewandte Chemie International Edition, 2020 - Wiley Online Library
DNA nanotechnology holds substantial promise for future biomedical engineering and the
development of novel therapies and diagnostic assays. The subnanometer‐level …

[HTML][HTML] The beauty and utility of DNA origami

P Wang, TA Meyer, V Pan, PK Dutta, Y Ke - Chem, 2017 - cell.com
This review focuses on fundamental advances in DNA origami design and its emerging
applications. For convenience, applications are coarsely categorized into nanofabrication …

A DNA-based nanocarrier for efficient gene delivery and combined cancer therapy

J Liu, L Song, S Liu, Q Jiang, Q Liu, N Li, ZG Wang… - Nano Letters, 2018 - ACS Publications
The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle
in realizing a viable gene-based medicine. Herein, we introduce a facile and universal …