Much success has been achieved with platinum-based chemotherapeutic agents, ie through
interactions with DNA. The long-term application of Pt complexes is thwarted by issues …

The clinical success of cisplatin and its derivatives has had an enormous impact on the
discovery of novel metal-based drugs. Extensive studies have focused on the interaction of …

Organometallic compounds are renowned for their remarkable applications in the field of
catalysis, but much less is known about their potential in chemical biology. Indeed, such …

Metallodrugs were classically screened against skin cancer (either in vitro or in vivo) at the
peak of the development of platinum anticancer agents. New systematic studies appeared in …

The synthesis and characterization of a new water-soluble iminophosphorane ligand TPA
NC (O)-2BrC6H4 (1, C, N-IM; TPA= 1, 3, 5-triaza-7-phosphaadamantane) is reported …

We report the synthesis and characterization of four neutral organometallic tethered
complexes,[Ru (η6-Ph (CH2) 3-ethylenediamine-NR) Cl], where R= methanesulfonyl (Ms …

1, 4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are
not restricted to 'classical'CNS treatments such as sedatives, epilepsy and muscle relaxants …

Leishmaniasis is a disease found throughout the (sub) tropical parts of the world caused by
protozoan parasites of the Leishmania genus. Despite the numerous problems associated …

An approach to the synthesis of triazolo [1, 5-a][1, 4] benzodiazepines comprising copper
catalyzed tandem Ullmann C–N coupling followed by azide-alkyne cycloaddition has been …

Bridge splitting reactions between [Pd (C 2, N-dmba)(μ-X)] 2 (dmba= N, N-
dimethylbenzylamine; X= Cl, I, N 3, NCO) and 2, 6-lutidine (lut) in the 1: 2 molar ratio at room …