The approval of venetoclax, a 'BH3-mimetic'antagonist of the BCL-2 anti-apoptotic protein,
for chronic lymphocytic leukemia represents a major milestone in translational apoptosis …

Abstract BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis.
They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as …

A promising approach to cancer therapy is to elicit apoptosis with “BH3 mimetic” drugs,
which target proteins of the BCL-2 family. As of yet, however, such drugs can target only …

Mitochondria, the energy supply factories for cell-life activities, play important roles in
controlling epigenetics, differentiation and initiation, and the execution of apoptosis. These …

Heterogeneity of tumors dictates an individual approach to anticancer treatment. Despite
their variability, almost all cancer cells demonstrate enhanced uptake and utilization of …

Among all BH3-only proteins known to date, most information is available on the biological
role and function of Bim (Bcl-2 interacting mediator of cell death)/BOD (Bcl-2 related ovarian …

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the Western
countries. The entire pathogenesis of CLL is not clear now, but defective regulation of …

The low efficiency of treatment strategies is one of the main obstacles to developing cancer
inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer …

Zhivotovsky B, Orrenius S (Institute of Environmental Medicine, Division of Toxicology,
Karolinska Institute, Stockholm, Sweden) Cell cycle and cell death in disease: past, present …

Mitochondrial malfunctioning is implicated in the pathogenesis of a variety of disorders,
including cancer and multiple neurodegenerative diseases, such as Parkinson's disease …