Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity

DG Bermudes - US Patent 9,616,114, 2017 - Google Patents
Bacterial Strains are provided having at least one of a reduced size, a sialic acid coat,
inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 agonists and/or …

Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity

DG Bermudes - US Patent 10,449,237, 2019 - Google Patents
Bacterial strains are provided having at least one of a reduced size, a sialic acid coat,
inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 antagonists and/or …

Multimeric elastin-like polypeptides

JA MacKay, M Shah, SF Hamm-Alvarez, H Guo… - US Patent …, 2022 - Google Patents
2022-03-25 Assigned to UNIVERSITY OF SOUTHERN CALIFORNIA reassignment
UNIVERSITY OF SOUTHERN CALIFORNIA ASSIGNMENT OF ASSIGNORS INTEREST …

Cargo carrying nanoparticles

R Iglesias, P Koria - US Patent 9,616,138, 2017 - Google Patents
Ignatovich et al. Complexes of Plasmid DNA with Basic Domain 47-57 of the HIV-1 Tat
Protein Are Transferred to Mammalian Cells by Endocytosis-mediated Pathways, The …

Chimeric protein toxins for expression by therapeutic bacteria

DG Bermudes - US Patent 11,129,906, 2021 - Google Patents
6/1993 Ladner et al. 8/1993 Cantor et al. 10/1993 Fuchs et al. 10/1993 De Greve et al.
1/1994 Baker et al. 1/1994 Sick et al. 3/1994 Wilcox et al. 4/1994 Sivasubramanian et al …

Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria

DG Bermudes - US Patent 11,180,535, 2021 - Google Patents
Bacteria with tumor-targeting capability express, surface displayed, secreted and/or
released modified chimeric therapeutic proteins with enhanced therapeutic activity against a …

Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity

DG Bermudes - US Patent 10,828,356, 2020 - Google Patents
Bacterial strains are provided having at least one of a reduced size, a sialic acid coat,
inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 antagonists and/or …

Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity

DG Bermudes - US Patent 10,729,731, 2020 - Google Patents
Bacterial strains are provided having at least one of a reduced size, a sialic acid coat,
inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 antagonists and/or …

Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity

DG Bermudes - US Patent 11,813,295, 2023 - Google Patents
Bacterial strains are provided having at least one of a reduced size, a sialic acid coat,
inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 antagonists and/or …

Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity

DG Bermudes - US Patent 11,633,435, 2023 - Google Patents
US11633435B1 - Modified bacteria having improved pharmacokinetics and tumor colonization
enhancing antitumor activity - Google Patents US11633435B1 - Modified bacteria having …