The advent of immune checkpoint inhibitors (ICIs) caused a paradigm shift both in drug
development and clinical practice; however, by virtue of their mechanism of action, the …

Immune checkpoint inhibitors (ICIs) have now been approved in numerous and diverse
cancer types and combination regimens. Effective recognition and treatment of ICI toxicities …

Immune-related adverse events (IrAEs) affecting the gastrointestinal (GI) tract and liver are
among the most frequent and most severe inflammatory toxicities from contemporary …

Background Rare cases of immune checkpoint inhibitor (ICI)-associated celiac disease (ICI-
CeD) have been reported, suggesting that disruption of tolerance mechanisms by ICIs can …

Immune checkpoint inhibitors have improved the survival in patients affected by an
increasing number of malignancies, but they may also trigger various autoimmune side …

Abstract Purpose of Review Checkpoint inhibitor (CPI) immunotherapy has transformed the
treatment of multiple cancers over the past decade, leading to durable remissions, but also …

Corticosteroids (CSs) are widely used in oncology, presenting several different indications.
They are useful for induction of apoptosis in hematological neoplasms, for management of …

Targeted cancer therapy agents are the latest development in cancer therapeutics. Although
the spectrum of their use continues to expand, ocular side effects are frequently encountered …

Background Immune checkpoint blockade in monotherapy or combinatorial regimens with
chemotherapy or radiotherapy have become an integral part of oncology in recent years …

Background Immunotherapies such as immune checkpoint inhibitors (ICI) are effective in
multiple tumor entities but induce a plethora of side effects. Comprehensive real-world …