Oxidative stress in spinal cord injury and antioxidant-based intervention

Z Jia, H Zhu, J Li, X Wang, H Misra, Y Li - Spinal cord, 2012 - nature.com
Study design: Literature review. Objectives: Spinal cord injury (SCI) remains a major public
health issue in developed countries as well as worldwide. The pathophysiology of SCI is …

Inflammation & apoptosis in spinal cord injury

N Zhang, Y Yin, SJ Xu, YP Wu… - Indian journal of medical …, 2012 - journals.lww.com
Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical
injury followed by an inflammatory process and apoptosis. Secondary insult is characterized …

[HTML][HTML] Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis

Y Zhou, LL Wen, YF Li, KM Wu, RR Duan… - Neural Regeneration …, 2022 - journals.lww.com
Mesenchymal stem cell (MSC) transplantation is a promising treatment strategy for spinal
cord injury, but immunological rejection and possible tumor formation limit its application …

Regulation of the JAK/STAT signaling pathway in spinal cord injury: an updated review

X Guo, C Jiang, Z Chen, X Wang, F Hong… - Frontiers in …, 2023 - frontiersin.org
Cytokines are involved in neural homeostasis and pathological processes associated with
neuroinflammation after spinal cord injury (SCI). The biological effect of cytokines, including …

Neuroprotective mechanisms of rutin for spinal cord injury through anti-oxidation and anti-inflammation and inhibition of p38 mitogen activated protein kinase pathway

H Song, X Zhang, W Wang, R Liu, K Zhao… - Neural regeneration …, 2018 - journals.lww.com
Rutin has anti-inflammatory, antioxidant, anti-viral, anti-tumor and immune regulatory effects.
However, the neuroprotective effects of rutin in spinal cord injury are unknown. The p38 …

[HTML][HTML] Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway

S Fu, R Lv, L Wang, H Hou, H Liu, S Shao - Saudi journal of biological …, 2018 - Elsevier
Resveratrol, a polyphenol found in various plants, including grapes, plums and peanuts has
shown various medIRInal properties, including antioxidant, protection of cardiovascular …

The cytoprotective effects of dantrolene: a ryanodine receptor antagonist

S Inan, H Wei - Anesthesia & Analgesia, 2010 - journals.lww.com
Calcium, as a second messenger, has an important role in a variety of cellular functions.
However, disruption of intracellular calcium homeostasis leads to cytotoxicity and cell death …

Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating

C Zhang, J Ma, L Fan, Y Zou, X Dang, K Wang, J Song - Tissue and Cell, 2015 - Elsevier
Studies on the pathology of spinal cord injury (SCI) have focused on inflammation-
associated neuronal apoptosis. The traditional Chinese medicine safranal has been studied …

The neuroprotective effect of syringic acid on spinal cord ischemia/reperfusion injury in rats

M Tokmak, Y Yuksel, MH Sehitoglu, M Guven, T Akman… - Inflammation, 2015 - Springer
Acute arterial occlusions via different vascular pathologies are the main causes of spinal
cord ischemia. We investigated neuroprotective effects of syringic acid on spinal cord …

A review on the etiology and management of pediatric traumatic spinal cord injuries

A Benmelouka, LS Shamseldin… - Advanced journal of …, 2019 - pmc.ncbi.nlm.nih.gov
Context: Pediatric traumatic spinal cord injury (SCI) is an uncommon presentation in the
emergency department. Severe injuries are associated with devastating outcomes and …