The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

Melatonin, as a neuroendocrine hormone, is produced primarily by the pineal gland.
Melatonin, a pleotropic molecule, acts as a free radical scavenger, antioxidant, and regulator …

Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many
lines of evidence suggest that the disturbances in circadian rhythm are responsible for the …

Oral melatonin is a potential alternative treatment for hypertension and nocturnal
hypertension. However, high‐quality and relevant meta‐analyses are lacking. This meta …

In this review we summarized the actual clinical data for a cardioprotective therapeutic role
of melatonin, listed melatonin and its agonists in different stages of development, and …

Background Several randomized controlled trials (RCTs) have explored the impact of
melatonin on body composition and blood pressure (BP). However, the findings from these …

The health problems associated with the aging process are becoming increasingly
widespread due to the increase in mean life expectancy taking place globally. While decline …

Background: The increasing incidence of chronic kidney disease (CKD), as a consequence
of the high prevalence of arterial hypertension and type 2 diabetes mellitus (T2DM) …

Aging is associated with weakening of the circadian system. The circadian amplitude of most
physiological variables is reduced, while the circadian phase becomes more labile and …

Cardiovascular diseases (CVDs) are the leading cause of death and disability worldwide. It
is essential to develop novel interventions to prevent/delay CVDs by targeting their …