Increased fracture risk represents an emerging and severe complication of diabetes. The
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …

A healthy skeleton depends on a continuous renewal and maintenance of the bone tissue.
The process of bone remodeling is highly controlled and consists of a fine-tuned balance …

Sclerostin is most recognized for its role in controlling bone formation but is also expressed
in the heart, aorta, coronary, and peripheral arteries. This review summarizes research on …

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …

Rationale: Vascular microcalcification increases the risk of rupture of vulnerable
atherosclerotic lesions. Inhibition of ERK1/2 reduces atherosclerosis in animal models while …

As a key regulator of bone homeostasis, sclerostin has garnered a lot of interest over the last
two decades. Although sclerostin is primarily expressed by osteocytes and is well known for …

There is cumulating evidence for a contribution of Wnt signaling pathways in multiple
processes involved in atherosclerosis and vascular aging. Wnt signaling plays a role in …

It has been recognized since comprehensive descriptions by Jean-Martin Charcot in 1868
and 1883 that development of what is usually known as neuropathic osteoarthropathy (or …

Charcot foot syndrome is an uncommon complication of diabetes but is potentially
devastating in its consequences. Outcome is made worse by widespread professional …

Background Here we study the effect of type 2 diabetes (T2DM) on bone cell precursors,
turnover and cytokines involved in the control of bone cell formation and activity. Methods …