Recent evidence indicates that ionizing radiation can enhance immune responses to
tumors. Advances in radiation delivery techniques allow hypofractionated delivery of …

Stereotactic body radiotherapy (SBRT) for patients with metastatic cancer, especially when
characterised by a low tumour burden (ie, oligometastatic disease), receiving targeted …

Alterations in gut microbiota impact the pathophysiology of several diseases, including
cancer. Radiotherapy (RT), an established curative and palliative cancer treatment, exerts …

Cancer immunotherapy has revolutionized the treatment landscape in medical oncology, but
its efficacy has been variable across patients. Biomarkers to predict such differential …

The tumor immune microenvironment is a determinant of response to cancer
immunotherapy and, in many cases, is prognostic for patient survival independently of the …

Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet
most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the …

Radiation therapy (RT) in some cases results in a systemic anticancer response known as
the abscopal effect. Multiple hypotheses support the role of immune activation initiated by …

Cancer-associated fibroblasts (CAFs) are an important component of the tumor
microenvironment that are involved in multiple aspects of cancer progression and …

Immunotherapy fails to cure most cancer patients. Preclinical studies indicate that
radiotherapy synergizes with immunotherapy, promoting radiation-induced antitumor …

Except for its use in palliative care, radiotherapy has been largely abandoned in the
management of ovarian cancer because of the recognised efficacy and lower toxicity of …