Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Sleep spindles: mechanisms and functions

LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study

ND Schiff, JT Giacino, CR Butson, EY Choi, JL Baker… - Nature medicine, 2023 - nature.com
Converging evidence indicates that impairments in executive function and information-
processing speed limit quality of life and social reentry after moderate-to-severe traumatic …

Deep brain stimulation of the thalamus restores signatures of consciousness in a nonhuman primate model

J Tasserie, L Uhrig, JD Sitt, D Manasova, M Dupont… - Science …, 2022 - science.org
Loss of consciousness is associated with the disruption of long-range thalamocortical and
corticocortical brain communication. We tested the hypothesis that deep brain stimulation …

[HTML][HTML] Thalamus modulates consciousness via layer-specific control of cortex

MJ Redinbaugh, JM Phillips, NA Kambi, S Mohanta… - Neuron, 2020 - cell.com
Functional MRI and electrophysiology studies suggest that consciousness depends on large-
scale thalamocortical and corticocortical interactions. However, it is unclear how neurons in …

Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group

A Comanducci, M Boly, J Claassen, M De Lucia… - Clinical …, 2020 - Elsevier
The analysis of spontaneous EEG activity and evoked potentials is a cornerstone of the
instrumental evaluation of patients with disorders of consciousness (DoC). The past few …

Thalamic dual control of sleep and wakefulness

TC Gent, M Bandarabadi, CG Herrera… - Nature …, 2018 - nature.com
Abstract Slow waves (0.5–4 Hz) predominate in the cortical electroencephalogram during
non-rapid eye movement (NREM) sleep in mammals. They reflect the synchronization of …

Principles of dynamic network reconfiguration across diverse brain states

JM Shine, RA Poldrack - NeuroImage, 2018 - Elsevier
Recent methodological advances have enabled researchers to track the network structure of
the human brain over time. Together, these studies provide novel insights into effective brain …

Replicability of time-varying connectivity patterns in large resting state fMRI samples

A Abrol, E Damaraju, RL Miller, JM Stephen, ED Claus… - Neuroimage, 2017 - Elsevier
The past few years have seen an emergence of approaches that leverage temporal changes
in whole-brain patterns of functional connectivity (the chronnectome). In this chronnectome …

Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep

K Liu, J Kim, DW Kim, YS Zhang, H Bao, M Denaxa… - Nature, 2017 - nature.com
Multiple populations of wake-promoting neurons have been characterized in mammals, but
few sleep-promoting neurons have been identified. Wake-promoting cell types include …