Molecular mechanisms that govern infection and antifungal resistance in Mucorales

C Lax, FE Nicolás, E Navarro… - … and Molecular Biology …, 2024 - Am Soc Microbiol
SUMMARY The World Health Organization has established a fungal priority pathogens list
that includes species critical or highly important to human health. Among them is the order …

GRP78 and integrins play different roles in host cell invasion during mucormycosis

A Alqarihi, T Gebremariam, Y Gu, M Swidergall… - MBio, 2020 - Am Soc Microbiol
Mucormycosis, caused by Rhizopus species, is a life-threatening fungal infection that occurs
in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic chemotherapy …

cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus

C Szebenyi, Y Gu, T Gebremariam, S Kocsubé… - MBio, 2023 - Am Soc Microbiol
Mucormycosis is an invasive fungal infection caused by certain members of the fungal order
of Mucorales. The species most frequently identified as the etiological agents of …

A novel resistance pathway for calcineurin inhibitors in the human-pathogenic mucorales Mucor circinelloides

S Vellanki, RB Billmyre, A Lorenzen, M Campbell… - MBio, 2020 - Am Soc Microbiol
Mucormycosis is an emerging lethal fungal infection in immunocompromised patients.
Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to …

Neem and Turmeric in the management of Covid Associated Mucormycosis (CAM) derived through network pharmacology

S Datta, I Sarkar, G Sen, A Sen - Journal of Biomolecular Structure …, 2023 - Taylor & Francis
Abstract Mucormycosis or 'Black Fungus' has been known to target immunocompromised
individuals even before the emergence of COVID-19. Nevertheless, the present …

Epidermal growth factor receptor signaling governs the host inflammatory response to invasive aspergillosis

H Liu, J Lin, QT Phan, VM Bruno, SG Filler - mBio, 2024 - journals.asm.org
The epidermal growth factor receptor (EGFR) has been identified as an epithelial cell
receptor for Mucorales fungi and Candida albicans. Blocking EGFR with small molecule …

Tornadic shear stress induces a transient, calcineurin-dependent hypervirulent phenotype in Mucorales molds

S Wurster, AM Tatara, ND Albert, AS Ibrahim… - MBio, 2020 - Am Soc Microbiol
Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and
mortality in victims of combat-related injuries, geometeorological disasters, and severe …

Central nervous system-infecting pathogens Escherichia coli and Cryptococcus neoformans exploit the host Pdlim2 for intracellular traversal and exocytosis in the …

Z Li, VM Bruno, KS Kim - Infection and immunity, 2021 - Am Soc Microbiol
Microbial penetration of the blood-brain barrier, a prerequisite for the development of central
nervous system (CNS) infection, involves microbial invasion, intracellular traversal, and …

[PDF][PDF] GRP78 and integrins play different roles in host cell invasion during mucormycosis. mBio 11: e01087-20

A Alqarihi, T Gebremariam, Y Gu, M Swidergall… - 2020 - researchgate.net
Mucormycosis, caused by Rhizopus species, is a life-threatening fungal infection that occurs
in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic chemotherapy …