Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …

The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

Gene expression profiling has uncovered the transcription factor Sox4 with upregulated
activity during TGF-β-induced epithelial-mesenchymal transition (EMT) in normal and …

SOX4 is an essential developmental transcription factor that regulates stemness,
differentiation, progenitor development, and multiple developmental pathways including …

Despite aggressive surgery, radiotherapy, and chemotherapy, treatment of malignant glioma
remains formidable. Although the concept of cancer stem cells reveals a new framework of …

Liver cancer has a tendency to develop asymptomatically in patients, so most patients are
diagnosed at a later stage. Accumulating evidence implicates that liver tumour-initiating cells …

Epithelial–mesenchymal transition (EMT) is a developmental program, which is associated
with breast cancer progression and metastasis. Here, we report that ectopic overexpression …

During nervous system development, neural stem cells give rise to many different types of
neurons and glia over an extended period. Little is known about the intrinsic factors that …

The progression of neurogenesis relies on proneural basic helix–loop–helix (bHLH)
transcription factors. These factors operate in undifferentiated neural stem cells and induce …

Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most
common cause of cancer-related mortality in western men. To investigate the mechanisms of …