Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Mammalian mitochondrial ribosomes (mitoribosomes) synthesize a small subset of proteins,
which are essential components of the oxidative phosphorylation machinery. Therefore, their …

Mitochondrial ribosomes (mitoribosomes) synthesize proteins encoded within the
mitochondrial genome that are assembled into oxidative phosphorylation complexes. Thus …

Mitochondria contain their own genetic information and a dedicated translation system to
express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and …

Mitochondria are the powerhouse of eukaryotic cells. They possess their own gene
expression machineries where highly divergent and specialized ribosomes, named …

In contrast to the bacterial translation machinery, mitoribosomes and mitochondrial
translation factors are highly divergent in terms of composition and architecture. There is …

Assembly of the mitoribosome is largely enigmatic and involves numerous assembly factors.
Little is known about their function and the architectural transitions of the pre-ribosomal …

Mitochondrial ribosomes are specialized for the synthesis of membrane proteins responsible
for oxidative phosphorylation. Mammalian mitoribosomes have diverged considerably from …

Leishmaniasis affects more than 12 million humans globally and a further 1 billion people
are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis coupled …

Protein synthesis by the ribosome requires large-scale rearrangements of the 'small'subunit
(SSU;∼ 1 MDa), including inter-and intra-subunit rotational motions. However, with nearly …