A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …

This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Purpose Brain metastasis (BM) is a leading cause of death from non–small-cell lung cancer
(NSCLC). Reasoning that activation of the epidermal growth factor receptor (EGFR) …

Radiation therapy plays an important role in the management of a wide range of cancers.
Besides innovations in the physical application of radiation dose, radiation therapy is likely …

During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent
chemoradiotherapy has improved cancer care dramatically. Significant contributions have …

Brain metastases (BM) occur frequently in many cancers, particularly non–small cell lung
cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with …

The microRNA (miR)-200s and their negative regulator ZEB1 have been extensively studied
in the context of the epithelial–mesenchymal transition. Loss of miR-200s has been shown …

In recent years, there have been multiple breakthroughs in our understanding of lung cancer
biology. Despite significant advances in molecular targeted therapies, DNA-damaging …

Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA
damage as well as mitochondria-dependent generation of reactive oxygen species. DNA …

Background. Glioblastoma (GBM) is the most common primary brain tumor, with dismal
prognosis. The failure of drug–radiation combinations with promising preclinical data to …