Insulin therapy became a reality in 1921 dramatically saving lives of people with diabetes,
but not protecting them from long-term complications. Clinically successful free islet implants …

Therapeutic cells encapsulated in immunobarrier devices have promise for treatment of a
variety of human diseases without immunosuppression. The absence of sufficient oxygen …

The use of immunoisolating macrodevices in islet transplantation confers the benefit of
safety and translatability by containing transplanted cells within a single retrievable device …

Type 1 diabetes (T1DM) affects one in every 400 children and adolescents in the US. Due to
the limitations of exogenous insulin therapy and whole pancreas transplantation, pancreatic …

Cell encapsulation has already shown its high potential and holds the promise for future cell
therapies to enter the clinics as a large scale treatment option for various types of diseases …

Despite significant advances in the field of transplantation in the past two decades, current
clinically available therapeutic options for immunomodulation remain fairly limited. The …

Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …

Although regarded as a promising treatment for type 1 diabetes, clinical islet transplantation
in the portal vein is still hindered by a low transplantation outcome. Alternative …

Pancreatic β-cells have been reported to be mechanosensitive to cellular
microenvironments, and subjecting the cells to more physiologically relevant …

Type 1 diabetes—or, more accurately, type 1A diabetes—is thought to arise from selective
im-munologically mediated destruction of the insulin-producing β-cells in the pancreatic …