Gene expression is a complex process that is essential to living organisms. Gene
expression plays the important role of converting information that is encoded in a gene into a …

Retinoids are metabolic derivatives of vitamin A and regulate the function of many tissues
and organs both prenatally and postnatally. Active retinoids, such as all trans-retinoic acid …

Transcription factors (TFs) exert their regulatory influence through the binding of enhancers,
resulting in coordination of gene expression programs. Active enhancers are often …

Biological systems consist of multiple organizational levels all densely interacting with each
other to ensure function and flexibility of the system. Simultaneous analysis of cross …

Gene regulatory networks inferred from RNA abundance data have generated significant
interest, but despite this, gene network approaches are used infrequently and often require …

Development of valid structure–activity relationships (SARs) is a key to the elucidation of
pathomechanisms of epigenetic diseases and the development of efficient, new drugs. The …

Abstract Cytochrome P450 (CYP) 3A is the most abundant CYP enzyme in the human liver,
and a functional impairment of this enzyme leads to unanticipated adverse reactions and …

Background So far, investigators have found numerous tumor suppressor genes (TSGs) and
oncogenes (OCGs) that control cell proliferation and apoptosis during cancer development …

Transcription factor activity is often controlled through the dynamic use of post-translational
modifications. Two such modifications are acetylation and sumoylation, which both occur on …

The regulation of gene transcription by transcription factors is a fundamental biological
process, yet the relations between transcription factors (TF) and their target genes (TG) are …