Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …

Proteases that cleave ubiquitin or ubiquitin-like proteins (UBLs) are critical players in
maintaining the homeostasis of the organism. Concordantly, their dysregulation has been …

Exploring the connection between ubiquitin-like modifiers (ULMs) and the DNA damage
response (DDR), we employed several advanced DNA damage and repair assay …

Abstract The SARS-CoV-2 envelope (E) protein is highly conserved among different viral
variants and important for viral assembly and production. Our recent study found that the E …

Chromatin is the context for all DNA-based molecular processes taking place in the cell
nucleus. The initial chromatin structure at the site of the DNA damage determines both …

The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing
and genome stability maintenance. Disruption of the spliceosome activity may lead to …

Background DNA damage response and repair (DDR) related signatures play an important
role in maintaining genome stability and other biological processes. It also affects the …

ABSTRACT DNA double-strand break (DSB) is the most dangerous type of DNA damage,
which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and …

Radiation therapy is a primary treatment for cancer, but radioresistance remains a significant
challenge in improving efficacy and reducing toxicity. Accumulating evidence suggests that …

PARP1 inhibitors (PARPis) are used for treatment of cancers with mutations in BRCA1 or
BRCA2 that are deficient in homologous recombination. The identification of modulators of …