Unleashing the power of bond cleavage chemistry in living systems
Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …
Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs
Prodrug approaches represent an excellent solution to certain pharmaceutical issues
commonly encountered in the drug discovery and development process. Along this line, the …
commonly encountered in the drug discovery and development process. Along this line, the …
Gas-mediated cancer bioimaging and therapy
Gas-involving cancer theranostics have attracted considerable attention in recent years due
to their high therapeutic efficacy and biosafety. We have reviewed the recent significant …
to their high therapeutic efficacy and biosafety. We have reviewed the recent significant …
Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide
Controlled activation is a critical component in prodrug development. Here we report a
concentration-sensitive platform approach for bioorthogonal prodrug activation by taking …
concentration-sensitive platform approach for bioorthogonal prodrug activation by taking …
Mechanisms and substituent effects of metal-free bioorthogonal reactions
T Deb, J Tu, RM Franzini - Chemical reviews, 2021 - ACS Publications
Reactions that occur under physiological conditions find diverse uses in the chemical and
biological sciences. However, the limitations that biological systems place on chemical …
biological sciences. However, the limitations that biological systems place on chemical …
Strategies toward organic carbon monoxide prodrugs
Conspectus Carbon monoxide is widely acknowledged as an important gasotransmitter in
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …
Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …
with a variety of pathophysiological and pharmacological functions, including …
External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release
Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …
Role of carbon monoxide in host–gut microbiome communication
CP Hopper, LK De La Cruz, KV Lyles… - Chemical …, 2020 - ACS Publications
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …
[HTML][HTML] Click chemistry and drug delivery: A bird's-eye view
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …
a large number of click reactions with a various characteristics, selection of appropriate …