Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions—such as loss of p53—that prevent or …

The p53 protein regulates the transcription of many different genes in response to a wide
variety of stress signals. Following DNA damage, p53 regulates key processes, including …

The transcription factor Myc is induced by mitogenic signals and regulates downstream
cellular responses. If overexpressed, Myc promotes malignant transformation. Myc …

Survivin is an inhibitor of apoptosis protein, which is over-expressed in most tumors.
Aberrant expression of survivin and loss of wild-type p53 in many tumors prompted us to …

As a novel semiconducting material, the inherent, direct, and appreciable band gap endows
BP with preferable optical and electronic properties other than graphene and transition …

We here report that miR‐17‐92 cluster is a novel target for p53‐mediated transcriptional
repression under hypoxia. We found the expression levels of miR‐17‐92 cluster were …

The functions of non-coding microRNAs (miRNAs) in tumorigenesis are just beginning to
emerge. Previous studies from our laboratory have identified a number of miRNAs that were …

The predominant function of the tumor suppressor p53 is transcriptional regulation. It is
generally accepted that p53-dependent transcriptional activation occurs by binding to a …

The p63 gene shows remarkable structural similarity to the p53 and p73 genes. Because of
two promoters, the p63 gene generates two types of protein isoforms, TAp63 and ΔNp63 …

DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response
composed of activation of stress signaling and DNA checkpoint functions. These are …