Understanding the signals that guide neuronal development and direct formation of axons,
dendrites, and synapses during wiring of the brain is a fundamental challenge in …

Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for
analyzing protein and peptide content in cells. The spatial resolution of MALDI mass …

The smooth surface structure of intracortical microelectrodes implanted within the nanometer‐
scale architecture of brain tissue may contribute to the foreign body response. Here, the …

Intracortical microelectrodes (IME) are neural devices that initially were designed to function
as neuroscience tools to enable researchers to understand the nervous system. Over the …

The emergent self-organization of a neuronal network in a developing nervous system is the
result of a remarkably orchestrated process involving a multitude of chemical, mechanical …

Biochemical separations are the heart of diagnostic assays and purification methods for
biologics. On-chip miniaturization and modularization of separation procedures will enable …

Neurotransmitters and neuromodulators are molecules within the nervous system that play
key roles in cell-to-cell communication. Upon stimulation, neurons release these signaling …

Studies on the degeneration and regeneration of neurons as individual compartments of
axons or somata can provide critical information for the clinical therapy of nervous system …

An array of design strategies have been targeted toward minimizing failure of implanted
microelectrodes by minimizing the chronic glial scar around the microelectrode under …

Culturing primary hippocampal neurons in vitro facilitates mechanistic interrogation of many
aspects of neuronal development. Dissociated embryonic hippocampal neurons can often …