Colicins are proteins produced by and toxic for some strains of Escherichia coli. They are
produced by strains of E. coli carrying a colicinogenic plasmid that bears the genetic …

The hydrolysis of phosphodiester bonds by metallonucleases is crucial to most aspects of
nucleic acid processing. In recent years, studies of the classical restriction endonucleases …

Protein design and engineering are evolving at an unprecedented pace leveraging the
advances in deep learning. Current models nonetheless cannot natively consider non …

The present invention relates to a method for the generation of compact Transcription
Activator-Like Effector Nucleases (TALENs) that can efficiently target and process double …

Nucleotidyl-transfer enzymes, which synthesize, degrade and rearrange DNA and RNA,
often depend on metal ions for catalysis. All DNA and RNA polymerases, MutH-like or …

It is more than 80 years since Gratia first described 'a remarkable antagonism between two
strains of Escherichia coli'. Shown subsequently to be due to the action of proteins (or …

DNA phosphorothioate (PT) modification, with a nonbridging phosphate oxygen substituted
by sulfur, represents a widespread epigenetic marker in prokaryotes and provides protection …

HNH endonucleases in bacteriophages play a variety of roles in the phage lifecycle as key
components of phage DNA packaging machines. The deep-sea thermophilic bacteriophage …

How proteins achieve high-affinity binding to a specific protein partner while simultaneously
excluding all others is a major biological problem that has important implications for protein …

The ββα-Me restriction endonuclease (REase) Hpy99I recognizes the CGWCG target
sequence and cleaves it with unusual stagger (five nucleotide 5′-recessed ends). Here we …