For the past 30 years, improvements in the survival of patients with osteosarcoma have been
mostly incremental. Despite evidence of genomic instability and a high frequency of …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-
sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic …

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

Osteosarcoma is the most common primary malignancy of bone, typically presenting in the
first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients …

Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high
degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS …

Osteosarcoma is a devastating but rare disease, whose study has illuminated both the basic
biology and clinical management of cancer over the past 30 years. These contributions have …

In the US, approximately 650 children are diagnosed with osteosarcoma and Ewing
sarcoma (ES) each year. Five‐year survival ranges from 65% to 75% for localized disease …

Purpose: Although multimodal chemotherapy has improved outcomes for patients with
osteosarcoma, the prognosis for patients who present with metastatic and/or recurrent …

High‐grade osteosarcoma is a tumor with a complex genomic profile, occurring primarily in
adolescents with a second peak at middle age. The extensive genomic alterations obscure …