The uniqueness of albumin as a carrier in nanodrug delivery

A Spada, J Emami, JA Tuszynski… - Molecular …, 2021 - ACS Publications
Albumin is an appealing carrier in nanomedicine because of its unique features. First, it is
the most abundant protein in plasma, endowing high biocompatibility, biodegradability …

[HTML][HTML] Strategies for preparing albumin-based nanoparticles for multifunctional bioimaging and drug delivery

FF An, XH Zhang - Theranostics, 2017 - ncbi.nlm.nih.gov
Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic
ingredient of human blood without immunogenicity and encouraged by its successful clinical …

A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

F Li, J Lu, J Liu, C Liang, M Wang, L Wang, D Li… - Nature …, 2017 - nature.com
Paclitaxel (PTX) is among the most commonly used first-line drugs for cancer chemotherapy.
However, its poor water solubility and indiscriminate distribution in normal tissues remain …

Emerging albumin-binding anticancer drugs for tumor-targeted drug delivery: current understandings and clinical translation

H Cho, SI Jeon, CH Ahn, MK Shim, K Kim - Pharmaceutics, 2022 - mdpi.com
Albumin has shown remarkable promise as a natural drug carrier by improving
pharmacokinetic (PK) profiles of anticancer drugs for tumor-targeted delivery. The …

Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy

SS Qi, JH Sun, HH Yu, SQ Yu - Drug delivery, 2017 - Taylor & Francis
To achieve superior therapeutic efficacy, the combination chemotherapy using two or more
anticancer drugs in clinical practice has been generally accepted as a feasible strategy. On …

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

L Guo, S Luo, Z Du, M Zhou, P Li, Y Fu, X Sun… - Nature …, 2017 - nature.com
Mesangial cells-mediated glomerulonephritis is a frequent cause of end-stage renal
disease. Here, we show that celastrol is effective in treating both reversible and irreversible …

Nanotechnology as a tool to overcome macromolecules delivery issues

LL Tundisi, JA Ataide, JSR Costa… - Colloids and Surfaces B …, 2023 - Elsevier
Nanocarriers can deliver drugs to specific organs or cells, potentially bridging the gap
between a drug's function and its interaction with biological systems such as human …

Human Serum Albumin Nanoparticles for Use in Cancer Drug Delivery: Process Optimization and In Vitro Characterization

N Lomis, S Westfall, L Farahdel, M Malhotra… - Nanomaterials, 2016 - mdpi.com
Human serum albumin nanoparticles (HSA-NPs) are widely-used drug delivery systems with
applications in various diseases, like cancer. For intravenous administration of HSA-NPs …

Impact of albumin based approaches in nanomedicine: Imaging, targeting and drug delivery

B Bhushan, V Khanadeev, B Khlebtsov… - Advances in colloid and …, 2017 - Elsevier
Abstracts A major challenge in the field of nanomedicine is to transform laboratory
innovations into commercially successful clinical products. In this campaign, a variety of …

Recent advances in the treatment of bone metastases and primary bone tumors: An up-to-date review

AE Bădilă, DM Rădulescu, AG Niculescu… - Cancers, 2021 - mdpi.com
Simple Summary Bone represents a common metastatic site for patients with advanced
cancers while also being associated with rare but challenging primary tumors. As the …