Haptoglobin: From hemoglobin scavenging to human health

A di Masi, G De Simone, C Ciaccio, S D'Orso… - Molecular Aspects of …, 2020 - Elsevier
Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

Potential markers for detection and monitoring of ovarian cancer

BJD Rein, S Gupta, R Dada, J Safi… - Journal of …, 2011 - Wiley Online Library
This paper reviews current screening techniques as well as novel biomarkers and their
potential role in early detection of ovarian cancer. Ovarian cancer is one of the most …

Biomarker discovery in breast cancer serum using 2‐D differential gel electrophoresis/MALDI‐TOF/TOF and data validation by routine clinical assays

HL Huang, T Stasyk, S Morandell, H Dieplinger… - …, 2006 - Wiley Online Library
In the present study, we used 2‐D differential gel electrophoresis (2‐D DIGE) and MS to
screen biomarker candidates in serum samples obtained from 39 patients with breast cancer …

Circulating haptoglobin is an independent prognostic factor in the sera of patients with epithelial ovarian cancer

C Zhao, L Annamalai, C Guo, N Kothandaraman… - Neoplasia, 2007 - Elsevier
OBJECTIVE: This study was conducted to evaluate the prognostic significance of
haptoglobin levels in the overall survival of patients presenting with various stages of …

Polymorphism of human haptoglobin and its clinical importance

VPA Wobeto, TR Zaccariotto, MF Sonati - Genetics and Molecular …, 2008 - SciELO Brasil
Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind
free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following …

Proteomic identification of haptoglobin α2 as a glioblastoma serum biomarker: implications in cancer cell migration and tumor growth

DM Kumar, B Thota, SV Shinde… - Journal of proteome …, 2010 - ACS Publications
Glioblastoma (GBM; grade IV astrocytoma) is the most malignant and common primary brain
tumor in adults. Using combination of 2-DE and MALDI-TOF MS, we analyzed 14 GBM and 6 …

Proteomics-based identification of α1-antitrypsin and haptoglobin precursors as novel serum markers in infiltrating ductal breast carcinomas

B Hamrita, K Chahed, M Trimeche, CL Guillier… - Clinica Chimica …, 2009 - Elsevier
BACKGROUND: The identification of pathological markers of breast cancer for either
diagnosis, treatment response or for survival is of critical importance. METHODS: Serum …

Multiple biomarker algorithms to predict epithelial ovarian cancer in women with a pelvic mass: Can additional makers improve performance?

RG Moore, A Blackman, MC Miller, K Robison… - Gynecologic …, 2019 - Elsevier
Introduction Management of a woman with a pelvic mass is complicated by difficulty in
discriminating malignant from benign disease. Many serum biomarkers have been …

Identification of important invasion and proliferation related genes in adrenocortical carcinoma

AM Alshabi, B Vastrad, IA Shaikh, C Vastrad - Medical Oncology, 2019 - Springer
Adrenocortical carcinoma (ACC) is an end‐stage hormonal syndrome. Although profound
attempts have been made to illuminate the pathogenesis, the molecular mechanisms of …

Caloric restriction inhibits up-regulation of inflammatory cytokines and TNF-α, and activates IL-10 and haptoglobin in the plasma of streptozotocin-induced diabetic rats

NH Ugochukwu, CL Figgers - The Journal of nutritional biochemistry, 2007 - Elsevier
Diabetes mellitus is a significant risk factor for cardiovascular diseases, and low-grade
systemic inflammation, mediated by oxidative stress, may play a central role. Caloric …