Natural products and their derivatives are important sources for drug discovery; however,
they usually have poor solubility and low activity and require structural modification. Amino …

Background The development and spread of artemisinin-resistant Plasmodium falciparum
malaria in Greater Mekong Subregion has created impetus for continuing global monitoring …

Introduction As malaria declines, low-density malaria infections (LMIs) represent an
increasing proportion of infections and may have negative impacts on child health and …

The emergence and spread of Plasmodium falciparum parasites resistant to artemisinin
derivatives and their partners in southeastern Asia threatens malaria control and elimination …

Despite the cytotoxicity and embryotoxicity previously reported artesunate is a
recommended drug to treat malaria for adults, children, and women in the first trimester of …

Introduction As malaria declines, low-density malaria infections (LMIs) represent an
increasing proportion of infections and may have negative impacts on child health and …

Background Artemisinin-based combination therapies (ACTs) have remained efficacious
treatments of acute falciparum malaria in many endemic areas but there is little evaluation of …

疟疾是一种严重危及生命的传染病, 对人类生活产生着深远影响. 青蒿素至今仍是世界卫生组织
推荐的临床抗疟一线用药, 其抗疟活性主要体现在过氧桥结构上. 以青蒿素类化合物为基础的 …

Background Early rising asexual parasitaemia (ERAP), initially defined as 'an increase in the
parasite count over the baseline pre-treatment level during the first 24 h of treatment'of …

Anaemia following Artemisinin-Based Combination Treatments of Uncomplicated Plasmodium
falciparum Malaria in Children: Temporal Patterns of Haematocrit and the Use of …