Methylation is an essential biochemical mechanism that is central to the transmission of life,
and crucially responsible for regulating gametogenesis and continued embryo development …

The agouti viable yellow (A vy) allele is an insertional mutation in the mouse genome
caused by a variably methylated intracisternal A particle (VM-IAP) retrotransposon. A vy …

Homocysteine is associated with several diseases, and a series of dietary factors are known
to modulate homocysteine levels. As mice are often used as model organisms to study the …

The mechanism behind transgenerational epigenetic inheritance is unclear, particularly
through the maternal grandparental line. We previously showed that disruption of folate …

One-carbon metabolism is an important metabolic pathway involved in many diseases, such
as congenital malformations, tumours, cardiovascular diseases, anaemia, depression …

Hematopoietic stem cells provide us with a life-long supply of blood cells. Hence, their
proper function is absolutely essential for life, and their dysfunction can lead to infectious …

One-carbon metabolism, including the folate cycle, has a crucial role in fetal development
though its molecular function is complex and unclear. The hypomorphic Mtrr gt allele is …

Abnormal uptake or metabolism of folate increases risk of human pregnancy complications,
though the mechanism is unclear. Here, we explore how defective folate metabolism …

The single nucleotide variation (SNV) assay holds significant value in the diagnosis of
genetic diseases. However, the wide application of SNV analysis in clinics meets many …

Elucidating how the environment affects human health will further our understanding of
disease risk and prevention, and our potential for adaptation, such as how metabolism …