In the development of cancer chemotherapy, besides the discovery of new anticancer drugs,
a variety of nanocarrier systems for the delivery of previously developed and new …

Apelin is a vasoactive peptide and is an endogenous ligand for APJ receptors, which are
widely expressed in blood vessels, heart, and cardiovascular regulatory regions of the brain …

Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based
immunotherapies. Here we perturbed genes in human melanoma cells to mimic loss-of …

To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and
acquire highly migratory and proliferative phenotypes. However, the molecular mechanisms …

Physiologically, brain tumors interact with surrounding vascular and glial cells, and change
their responses to survive in brain tissue‐specific microenvironments. A major difficulty in …

Apelin, a regulatory peptide, is a ligand of the APJ receptor that belongs to the G protein-
coupled receptor family. Apelin and APJ are widely distributed in the body and play potential …

Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-
existing blood vessels to form new ones by a process termed angiogenesis. During …

Background: The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process
contributed by the accumulation of molecular alterations. We identified Apelin (APLN) as an …

Apelin is a bioactive peptide with diverse physiological actions on many tissues mediated by
its interaction with its specific receptor APJ. Since the identification of apelin and APJ in …

Apelin is an endogenous ligand of the apelin receptor (APJ), a seven-transmembrane G
protein-coupled receptor. Apelin/APJ system has a wide tissue distribution in the brain as …