Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

The tight junction proteins claudins are abnormally regulated in several human cancers. In
particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias …

Cancer is a multistep process involving cooperation between oncogenic or tumor
suppressor mutations and interactions between the tumor and surrounding normal tissue …

To generate different cell types, some cells can segregate protein determinants into one of
their two daughter cells during mitosis. In Drosophila neuroblasts, the Par protein complex …

E-cadherin is a tumor suppressor protein with a well-established role in cell–cell adhesion.
Adhesion could contribute to tumor suppression either by physically joining cells or by …

Abstract Both ErbB1 and ErbB2 are overexpressed or amplified in breast tumours. To
examine the effects of activating ErbB receptors in a context that mimics polarized epithelial …

Loss of cell polarity and cancer are tightly correlated, but proof for a causative relationship
has remained elusive. In stem cells, loss of polarity and impairment of asymmetric cell …

The neoplastic tumour suppressors, Scribble, Dlg and Lgl, originally discovered in the
vinegar fly Drosophila melanogaster, are currently being actively studied for their potential …

Purpose: Claudin proteins represent a large family of integral membrane proteins crucial for
tight junction (TJ) formation and function. Claudins have been shown to be up-regulated in …

Interactions between ligands and receptors are central to communication between cells and
tissues. Human airway epithelia constitutively produce both a ligand, the growth factor …