Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

A century ago, Cajal noted striking similarities between the neural circuits that underlie
vision in vertebrates and flies. Over the past few decades, structural and functional studies …

A fundamental goal of genetics and functional genomics is to identify and mutate every gene
in model organisms such as Drosophila melanogaster. The Berkeley Drosophila Genome …

RNA-mediated interference (RNAi) is a recently discovered method to determine gene
function in a number of organisms, including plants 1, nematodes 2, Drosophila 3, 4 …

The Drosophila eye is a powerful model system to study the dynamics of cell differentiation,
cell state transitions, cell maturation, and pattern formation. However, a high-resolution …

Cells in the Drosophila eye are determined by inductive signalling. Here I describe a new
model of eye development that explains how simple intercellular signals could specify the …

Research into new methods to identify genes in anonymous genomic sequences has been
going on for more than 15 years. Over this period of time, the field has evolved from the …

How multifunctional signals combine to specify unique cell fates during pattern formation is
not well understood. Here, we demonstrate that together with the transcription factor …

Different classes of photoreceptors (PRs) allow animals to perceive various types of visual
information. In the Drosophila eye, the outer PRs of each ommatidium are involved in motion …

Pax6, a member of the paired-box family of transcription factors, is critical for oculogenesis in
both vertebrates and insects. Identification of potential vertebrate Pax6 targets has been …