Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Prenatal and postnatal myogenesis share many cellular and molecular aspects. Myogenic
regulatory factors are basic Helix-Loop-Helix transcription factors that indispensably …

Growth and maintenance of skeletal muscle fibres depend on coordinated activation and
return to quiescence of resident muscle stem cells (MuSCs). The transcription factor …

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

Each skeletal muscle acquires its unique size before birth, when terminally differentiating
myocytes fuse to form a defined number of multinucleated myofibres. Although mice in which …

Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging which causes an
involution of muscle function and strength. Satellite cells (Sc) are myogenic stem cells, which …

Background Sarcopenia is a common and progressive skeletal muscle disorder
characterized by atrophic muscle fibres and contractile dysfunction. Accumulating evidence …

Muscle tissue engineering is a promising therapeutic strategy for volumetric muscle loss
(VML). Among them, decellularized extracellular matrix (dECM) biological scaffolds have …

Mechanical signals, such as those evoked by maximal-intensity contractions (MICs), can
induce an increase in muscle mass. Rapamycin-sensitive signaling events are widely …