Challenges in Therapeutic Drug Monitoring: Optimizing Biological Treatments in Patients With Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory …

K Papamichael, G Stocco… - Therapeutic Drug …, 2023 - journals.lww.com
Background: Therapeutic drug monitoring (TDM) is a decision-making tool for optimizing the
use of certain therapies. In this article, the authors review the role of proactive TDM of …

Optimizing therapeutic drug monitoring in inflammatory bowel disease: a focus on therapeutic monoclonal antibodies

K Papamichael, AS Cheifetz - Expert Opinion on Drug Metabolism …, 2021 - Taylor & Francis
Introduction Therapeutic drug monitoring (TDM) is useful for optimizing monoclonal
antibodies (mAbs) for the treatment of immune-mediated inflammatory disorders including …

A model-based tool for guiding infliximab induction dosing to maximize long-term deep remission in children with inflammatory bowel diseases

W Kantasiripitak, SG Wicha, D Thomas… - Journal of Crohn's …, 2023 - academic.oup.com
Abstract Background and Aims Adequate infliximab concentrations during induction
treatment are predictive for deep remission [corticosteroid-free clinical and endoscopic …

[HTML][HTML] Advances in therapeutic drug monitoring in biologic therapies for pediatric inflammatory bowel disease

A Kapoor, E Crowley - Frontiers in Pediatrics, 2021 - frontiersin.org
In the current era of treat-to-target strategies, therapeutic drug monitoring (TDM) has
emerged as a potential tool in optimizing the efficacy of biologics for children diagnosed with …

Therapeutic drug monitoring to improve outcome of anti-TNF drugs in pediatric inflammatory bowel disease

R Franca, D Curci, M Lucafo, G Decorti… - Expert Opinion on Drug …, 2019 - Taylor & Francis
Introduction: Medical treatment of pediatric inflammatory bowel diseases (IBD) has been
greatly changed by the introduction of a number of biologic agents that are able to target …

Pharmacogenetic variants of infliximab response in young patients with inflammatory bowel disease

D Curci, M Lucafò, A Cifù, M Fabris… - Clinical and …, 2021 - Wiley Online Library
Infliximab is commonly used in inflammatory bowel disease (IBD), however, differences in
clinical response among patients are common. Several studies have considered the …

Therapeutic Drug Monitoring of Anti-TNFα Inhibitors: A Matter of Cut-Off Ranges

S Cheli, D Savino, F Penagini, G Zuccotti, G Zuin… - Pharmaceutics, 2023 - mdpi.com
Therapeutic drug monitoring (TDM) is a useful tool for optimising the use of anti-TNFα
inhibitors in patients with inflammatory bowel diseases (IBDs). Recently, point-of-care …

Infliximab monitoring in Crohn's disease: a neural network approach for evaluating disease activity and immunogenicity

LEM Gomes, LM Genaro, MM Castro… - Therapeutic …, 2024 - journals.sagepub.com
Background: The treatment for Crohn's disease (CD) has increasingly required the use of
biological agents. Safe and affordable tests have led to the active implementation of …

[PDF][PDF] Development and validation of enzyme-linked immunosorbent assays for the measurement of infliximab and anti-drug antibody levels

D Xiang, N Li, L Liu, H Yu, X Li, T Zhao, D Liu, X Gong - Heliyon, 2023 - cell.com
Infliximab and its anti-drug antibody (ADA) serum concentrations exhibit a strong correlation
with clinical response and loss of response. The use of therapeutic drug monitoring to …

Enhancing Therapeutic Drug Monitoring in Inflammatory Bowel Disease: A Comparative Analysis of Rapid Point-of-Care Infliximab, Adalimumab and Anti-Drug …

FJ Toja-Camba, L García-Quintanilla… - Pharmaceutics, 2023 - mdpi.com
The introduction of point-of-care (POC) assays into clinical practice in patients with
inflammatory disease enables on-demand therapeutic decision making. The aim of this …