Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

H Tian, T Zhang, S Qin, Z Huang, L Zhou, J Shi… - Journal of hematology & …, 2022 - Springer
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

AO Elzoghby, MA Abdelmoneem, IA Hassanin… - Biomaterials, 2020 - Elsevier
Recent progress in protein-based nanomedicine, inspired by the success of Abraxane®
albumin-paclitaxel nanoparticles, have resulted in novel therapeutics used for treatment of …

Apoptotic mechanisms of quercetin in liver cancer: recent trends and advancements

G Sethi, P Rath, A Chauhan, A Ranjan, R Choudhary… - Pharmaceutics, 2023 - mdpi.com
Due to rising incidence rates of liver cancer and worries about the toxicity of current
chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy …

Effective dose/duration of natural flavonoid quercetin for treatment of diabetic nephropathy: A systematic review and meta-analysis of rodent data

Z Li, H Deng, X Guo, S Yan, C Lu, Z Zhao, X Feng, Q Li… - Phytomedicine, 2022 - Elsevier
Background Given the challenges on diabetic nephropathy (DN) treatment, research has
been carried out progressively focusing on dietary nutrition and natural products as a novel …

Coacervation‐Driven Semipermeable Nanoreactors for Enzymatic Cascade‐Mediated Cancer Combination Therapy with Enhanced Efficacy

M Lin, X Lv, H Wang, L Shu, H Wang… - Advanced …, 2024 - Wiley Online Library
Utilizing enzyme cascades as a promising approach for targeted cancer therapies holds
significant potential, yet its clinical effectiveness is substantially hindered by functional …

Zein-based nano-delivery systems for encapsulation and protection of hydrophobic bioactives: A review

X Yan, M Li, X Xu, X Liu, F Liu - Frontiers in Nutrition, 2022 - frontiersin.org
Zein is a kind of excellent carrier materials to construct nano-sized delivery systems for
hydrophobic bioactives, owing to its unique interfacial behavior, such as self-assembly and …

Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid as specific ligands for targeting nanosystems in the treatment of liver cancer

LA Stecanella, APR Bitencourt, GR Vaz, E Quarta… - Pharmaceutics, 2021 - mdpi.com
Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid, obtained from the
plant Glycyrrhiza glabra, have numerous pharmacological activities, such as anti …

Combined anti-hepatocellular carcinoma therapy inhibit drug-resistance and metastasis via targeting “substance P-hepatic stellate cells-hepatocellular carcinoma” …

Z Li, F Wang, Y Li, X Wang, Q Lu, D Wang, C Qi, C Li… - Biomaterials, 2021 - Elsevier
Peripheral nerves have emerged as the important components in tumor microenvironment
(TME), which could activate hepatic stellate cells (HSCs) by secreting substance P (SP) …

A novel 'smart'PNIPAM-based copolymer for breast cancer targeted therapy: Synthesis, and characterization of dual pH/temperature-responsive lactoferrin-targeted …

ORM Metawea, MA Abdelmoneem, NS Haiba… - Colloids and Surfaces B …, 2021 - Elsevier
Despite the active research towards introducing novel anticancer agents, the long-term
sequelae and side effects of chemotherapy remain the major obstacle to achieving clinical …

Chondroitin/Lactoferrin-dual functionalized pterostilbene-solid lipid nanoparticles as targeted breast cancer therapy

S Aly, AH El-Kamel, E Sheta, SE El-Habashy - International Journal of …, 2023 - Elsevier
Breast cancer remains the leading cause of cancer-associated mortality in women.
Research investigating novel therapeutic approaches is thus crucial, including …