Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Cheminformatics in natural product‐based drug discovery

Y Chen, J Kirchmair - Molecular Informatics, 2020 - Wiley Online Library
This review seeks to provide a timely survey of the scope and limitations of cheminformatics
methods in natural product‐based drug discovery. Following an overview of data resources …

Propagating annotations of molecular networks using in silico fragmentation

RR da Silva, M Wang, LF Nothias… - PLoS computational …, 2018 - journals.plos.org
The annotation of small molecules is one of the most challenging and important steps in
untargeted mass spectrometry analysis, as most of our biological interpretations rely on …

Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules

BK Okada, MR Seyedsayamdost - FEMS microbiology reviews, 2017 - academic.oup.com
Natural products have traditionally served as a dominant source of therapeutic agents. They
are produced by dedicated biosynthetic gene clusters that assemble complex, bioactive …

Concepts and methods to access novel antibiotics from actinomycetes

JJ Hug, CD Bader, M Remškar, K Cirnski, R Müller - Antibiotics, 2018 - mdpi.com
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

Data resources for the computer-guided discovery of bioactive natural products

Y Chen, C de Bruyn Kops… - Journal of chemical …, 2017 - ACS Publications
Natural products from plants, animals, marine life, fungi, bacteria, and other organisms are
an important resource for modern drug discovery. Their biological relevance and structural …

The potential contribution of the natural products from Brazilian biodiversity to bioeconomy

M Valli, HM Russo, VS Bolzani - Anais da Academia Brasileira de …, 2018 - SciELO Brasil
The development of our society has been based on the use of biodiversity, especially for
medicines and nutrition. Brazil is the nation with the largest biodiversity in the world …

[PDF][PDF] Secondary metabolites of marine microbes: From natural products chemistry to chemical ecology

LE Petersen, MY Kellermann… - YOUMARES 9-The …, 2020 - library.oapen.org
Marine natural products (MNPs) exhibit a wide range of pharmaceutically relevant
bioactivities, including antibiotic, antiviral, anticancer, or anti-inflammatory properties …

The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro

T Lane, M Anantpadma, JS Freundlich, RA Davey… - Pharmaceutical …, 2019 - Springer
Abstract Purpose Since the 2014 Ebola virus (EBOV) outbreak in West Africa there has been
considerable effort towards developing drugs to treat Ebola virus disease and yet to date …

Current status and contemporary approaches to the discovery of antitumor agents from higher plants

G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …