Fluorine does not belong to the pool of chemical elements that nature uses to build organic
matter. However, chemists have exploited the unique properties of fluorine and produced …

2, 2, 2-Trifluorodiazoethane (CF3CHN2) has been proven to be a valuable reagent for the
rapid synthesis of various classes of trifluoromethyl-substituted organic molecules in both …

The relevance of the‐CF2H moiety has attracted considerable attention from organic
synthetic and medicinal chemistry communities, because this group can act as a more …

Organofluorine chemistry is an area of tremendous expansion. 1 The field of applications is
impressively wide in scope and has the potential to concern all fields of society. Indeed …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

Let's avoid the risk! The title transformation has been developed for the synthesis of
trifluoromethyl‐substituted cyclopropane derivatives (see scheme). It avoids the preparation …

Although diazoalkanes find regular application in organic synthesis, the synthesis and
application of their fluorinated homologues was long neglected. First described in 1943 …

We disclose an efficient one‐pot transformation of trifluorodiazoethane and higher
perfluorinated homologues with various nitroolefins. This method takes advantage of the …

Functionalized proline residues have diverse applications. Herein we describe a practical
approach, proline editing, for the synthesis of peptides with stereospecifically modified …

3-Trifluoromethylpyrazole is the core unit of many drugs, agrochemicals, and related
candidates.[1] Among them are Celecoxib and Mavacoxib (antiarthritic), SC-560 (antitumor) …