Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy

P Yadav, R Yadav, S Jain… - Chemical biology & drug …, 2021 - Wiley Online Library
Caspases, a group of protease enzymes (cysteine proteases), exist as inactive zymogens in
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …

Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review

M Bashir, A Bano, AS Ijaz, BA Chaudhary - Molecules, 2015 - mdpi.com
Carbazoles represent an important class of heterocycles. These have been reported to
exhibit diverse biological activities such as antimicrobial, antitumor, antiepileptic …

Polycarbazole and its derivatives: Synthesis and applications. A review of the last 10 years

F Bekkar, F Bettahar, I Moreno, R Meghabar… - Polymers, 2020 - mdpi.com
Polycarbazole and its derivatives have been extensively used for the last three decades,
although the interest in these materials briefly decreased. However, the increasing demand …

Antidiabetic activities of alkaloids isolated from medicinal plants

I Muhammad, N Rahman, U Nishan… - Brazilian Journal of …, 2021 - SciELO Brasil
Diabetes mellitus is a metabolic disorder affecting a great part of population around the
world. It is the fifth leading death causing disease in the world and its cases are increasing …

New carbazole linked 1, 2, 3-triazoles as highly potent non-sugar α-glucosidase inhibitors

S Iqbal, MA Khan, K Javaid, R Sadiq… - Bioorganic …, 2017 - Elsevier
In the present study, a series of new carbazole linked 1 H-1, 2, 3-triazoles (2–27) were
synthesized via click reaction of N-propargyl-9H-carbazole (1) and azides of appropriate …

9, 9′‐Bicarbazole: New molecular skeleton for organic light‐emitting diodes

XY Liu, YL Zhang, X Fei, LS Liao… - Chemistry–A European …, 2019 - Wiley Online Library
Carbazole is a classic tricyclic aromatic compound that has been widely used in organic
optoelectronics. Appropriate functionalization on its aromatic rings will significantly increase …

One‐Pot Sequential Propargylation/Cycloisomerization: A Facile [4+ 2]‐Benzannulation Approach to Carbazoles

C Raji Reddy, R Rani Valleti… - Chemistry–A European …, 2016 - Wiley Online Library
Abstract A novel one‐pot [4+ 2]‐benzannulation approach to substituted carbazoles is
accomplished by acid‐catalyzed C3‐propargylation of 2‐alkenyl/aryl indoles with 1‐aryl …

Designing and theoretical study of benzocarbazole-based D-π-D type small molecules donor for organic solar cells

H Etabti, A Fitri, AT Benjelloun, M Benzakour… - Journal of Molecular …, 2023 - Elsevier
Seven new molecules (S1–S7) of D-π-D type have been designed for organic photovoltaic
applications. The DFT and TD-DFT methods were used to investigate the effect of different …

Recent developments in the synthesis of N‐heterocyclic compounds as α‐amylase inhibitors via in‐vitro and in‐silico analysis: Future drugs for treating diabetes

P Garg, RS Rawat, H Bhatt, S Kumar… - …, 2022 - Wiley Online Library
In nature, N‐heterocyclic compounds and their derivatives are abundant. They serve as the
building blocks of many biological entities, such as enzymes, alkaloids, hormones …

Inhibition of Human Topoisomerase II by N,N,N‐Trimethylethanammonium Iodide Alkylcarbazole Derivatives

C Saturnino, A Caruso, D Iacopetta, C Rosano… - …, 2018 - Wiley Online Library
Chemotherapy is used for the treatment of all stages of breast cancer, including the
metastatic stage of the disease. Treatment regimens are generally tailored for each patient …