Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies
examining plaque-associated proteins have shown these additional proteins are important; …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB)
exists between the blood microcirculation system and the brain parenchyma. The normal …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Recent epidemiological and clinico-pathologic data suggest overlaps between Alzheimer
disease (AD) and cerebrovascular lesions that may magnify the effect of mild AD pathology …

Thinning and discontinuities within the vascular basement membrane (VBM) are associated
with leakage of the plasma protein prothrombin across the blood–brain barrier (BBB) in …

The extracellular matrix (ECM) is known to regulate important processes in neuronal cell
development, activity and growth. It is associated with the structural stabilization of neuronal …

Background Neurodegenerative disorders are a group of age-associated diseases
characterized by progressive degeneration of the structure and function of the CNS. Two key …