Predicting novel microRNA: a comprehensive comparison of machine learning approaches

G Stegmayer, LE Di Persia, M Rubiolo… - Briefings in …, 2019 - academic.oup.com
Motivation The importance of microRNAs (miRNAs) is widely recognized in the community
nowadays because these short segments of RNA can play several roles in almost all …

Hepatitis B Virus and microRNAs: A Bioinformatics Approach

V Zulian, G Fiscon, P Paci, AR Garbuglia - International Journal of …, 2023 - mdpi.com
In recent decades, microRNAs (miRNAs) have emerged as key regulators of gene
expression, and the identification of viral miRNAs (v-miRNAs) within some viruses, including …

On the performance of pre-microRNA detection algorithms

MD Saçar Demirci, J Baumbach, J Allmer - Nature communications, 2017 - nature.com
MicroRNAs are crucial for post-transcriptional gene regulation, and their dysregulation has
been associated with diseases like cancer and, therefore, their analysis has become …

Deep neural architectures for highly imbalanced data in bioinformatics

LA Bugnon, C Yones, DH Milone… - IEEE Transactions on …, 2019 - ieeexplore.ieee.org
In the postgenome era, many problems in bioinformatics have arisen due to the generation
of large amounts of imbalanced data. In particular, the computational classification of …

Novel SARS-CoV-2 encoded small RNAs in the passage to humans

GA Merino, J Raad, LA Bugnon, C Yones… - …, 2020 - academic.oup.com
Abstract Motivation The Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)
has recently emerged as the responsible for the pandemic outbreak of the coronavirus …

miRe2e: a full end-to-end deep model based on transformers for prediction of pre-miRNAs

J Raad, LA Bugnon, DH Milone, G Stegmayer - Bioinformatics, 2022 - academic.oup.com
Motivation MicroRNAs (miRNAs) are small RNA sequences with key roles in the regulation
of gene expression at post-transcriptional level in different species. Accurate prediction of …

[HTML][HTML] Deep Learning for the discovery of new pre-miRNAs: Helping the fight against COVID-19

LA Bugnon, J Raad, GA Merino, C Yones, F Ariel… - Machine Learning with …, 2021 - Elsevier
Abstract The Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) has been
recently found responsible for the pandemic outbreak of a novel coronavirus disease …

High class-imbalance in pre-miRNA prediction: a novel approach based on deepSOM

G Stegmayer, C Yones, L Kamenetzky… - … /ACM transactions on …, 2016 - ieeexplore.ieee.org
The computational prediction of novel microRNA within a full genome involves identifying
sequences having the highest chance of being a miRNA precursor (pre-miRNA). These …

MicroRNA categorization using sequence motifs and k-mers

M Yousef, W Khalifa, İE Acar, J Allmer - BMC bioinformatics, 2017 - Springer
Background Post-transcriptional gene dysregulation can be a hallmark of diseases like
cancer and microRNAs (miRNAs) play a key role in the modulation of translation efficiency …

Alternative use of miRNA-biogenesis co-factors in plants at low temperatures

DA Ré, PLM Lang, C Yones, AL Arce… - …, 2019 - journals.biologists.com
Plants use molecular mechanisms to sense temperatures, trigger quick adaptive responses
and thereby cope with environmental changes. MicroRNAs (miRNAs) are key regulators of …