Embryonic neocortical development depends on balanced production of progenitors and
neurons. Genetic mutations disrupting progenitor mitosis frequently impair neurogenesis; …

A mutation in the centrosomal‐P4. 1‐associated protein (CPAP) causes Seckel syndrome
with microcephaly, which is suggested to arise from a decline in neural progenitor cells …

Centrosomes are the microtubule-organizing centers of animal cells that organize
interphase microtubules and mitotic spindles. Centrioles are the microtubule-based …

Intellectual disability (ID) is a common condition with considerable genetic heterogeneity.
Next-generation sequencing of large cohorts has identified an increasing number of genes …

Cell division terminates with cytokinesis and cellular separation. Autosomal-recessive
primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by a …

Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the
purine nucleotide cycle. ADSL deficiency (ADSLD) causes numerous neurodevelopmental …

Microtubule-based centrioles in the centrosome mediate accurate bipolar cell division,
spindle orientation, and primary cilia formation. Cellular checkpoints ensure that the …

Background Promyelocytic leukemia zinc finger (Plzf), a transcriptional regulator involved in
a lot of important biological processes during development, has been implied to maintain …

Maintenance of genome stability is a critical condition that ensures that daughter cells
acquire an accurate copy of the genetic information from the parental cell. DNA replication …

Abstract 3'non-homologous tail removal (3'NHTR) is a required step in certain forms of
double strand break repair (DSBR). The process of 3'NHTR is unique in that all of the …