A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …

The loss of control over drug intake that occurs in addiction was initially believed to result
from disruption of subcortical reward circuits. However, imaging studies in addictive …

Human neuroimaging studies suggest that neural cue reactivity is strongly associated with
indices of drug use, including addiction severity and treatment success. However, little is …

In the past decade, research has accumulated suggesting that excessive Internet use can
lead to the development of a behavioral addiction. Internet addiction has been considered …

Despite intensive scientific investigation and public health imperatives, drug addiction
treatment outcomes have not significantly improved in more than 50years. Non-invasive …

A striking neurochemical form of compartmentalization has been found in the striatum of
humans and other species, dividing it into striosomes and matrix. The function of this …

The anterior cingulate cortex (ACC) is part of a network implicated in the development of self-
regulation and whose connectivity changes dramatically in development. In previous studies …

More than 80% of addicted individuals fail to seek treatment, which might reflect impairments
in recognition of severity of disorder. Considered by some as intentional deception, such …

Understanding the cognitive sequela of repeated cocaine use is a growing area of research
and is crucial to the development of cognitive models of addiction. We systematically …

The repeated use of drugs that directly or indirectly stimulate dopamine transmission carry
addiction liability and produce enduring pathological changes in the brain circuitry that …