Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

The cell nucleus is structurally and functionally organized by lamins, intermediate filament
proteins that form the nuclear lamina. Point mutations in genes that encode a specific subset …

Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9
(H3K9me) is critical for maintaining organismal viability and tissue integrity. Here we show …

Chromatin disorganization is one of the major alterations linked to prelamin A processing
impairment. In this study we demonstrate that BAF is necessary to modulate prelamin A …

Epigenomic change and stem cell exhaustion are two of the hallmarks of aging.
Accumulation of molecular damage is thought to underlie aging, but the precise molecular …

Senescent cell clearance is emerging as a promising strategy for treating age-related
diseases. Senolytics are small molecules that promote the clearance of senescent cells; …

Almost since the discovery that mutations in the LMNA gene, encoding the nuclear structure
components lamin A and C, lead to Hutchinson-Gilford progeria syndrome, people have …

Defective nuclear lamina protein lamin A is associated with premature aging. Casein kinase
2 (CK2) binds the nuclear lamina, and inhibiting CK2 activity induces cellular senescence in …

The nuclear matrix protein lamin A is a multifunctional protein with roles in DNA replication
and repair, gene activation, transcriptional regulation, and maintenance of higher-order …

Genomic instability is not only a hallmark of senescent cells but also a key factor driving
cellular senescence, and replication stress is the main source of genomic instability …